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  1. General Info
  2. Source Info
  3. Effects Info
  4. Reference
Phytochemical Details
01. General Information
Name Codonopsis pilosula polysaccharide
PubChem CID /
Structure 2D-img
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2D MOL 3D MOL
02. Source Information of Phytochemical
Codonopsis pilosula Even
Chineses Pinyin DangShen
Use Part Root
Habitat HuBei, HuNan, SiChuan, GuiZhou
Flavor Sweet
Meridian Tropism Lung; Spleen
03. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Drug(s) whose efficacy can be enhanced by this phytochemical
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Combination Pair ID: 1039
Ref_1
Pair Name Codonopsis pilosula polysaccharide, Dacarbazine
Partner Name Dacarbazine
Disease Info [ICD-11: 2C30] Melanoma Investigative
Gene Regulation Up-regulation Expression IL1B hsa3553
Up-regulation Expression IL6 hsa3569
Up-regulation Expression NOS2 hsa4843
In Vitro Model B16 Mouse melanoma Mus musculus (Mouse) CVCL_F936
In Vivo Model To establish the tumor model, 1 × 106 B16 cells were suspended in 1 mL PBS buffer and 100 μL was injected subcutaneously into the right hind groin of each mouse.
Result It could be deduced that GLCP, CPCP and dCPP hold great potential as safe therapeutic options for melanoma and an immune-modulator which may require further exploration.
04. Reference
No. Title Href
1 Codonopsis pilosula polysaccharide in synergy with dacarbazine inhibits mouse melanoma by repolarizing M2-like tumor-associated macrophages into M1-like tumor-associated macrophages. Biomed Pharmacother. 2021;142:112016. doi:10.1016/j.biopha.2021.112016 Click
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